Lastminute.com reviewer Cheryl adds, "Places you saw: Romer area, river/museum areas have a vibe.
Learn from experience: Frankfurt is good to explore for one day, but combined with a vineyard tour around Wiesbaden is a nice weekend. Easy to get the train from the airport to central Frankfurt for about £5. The area around the Frankfurt am Main station is run-down but with a few minutes walk, you can be into central Frankfurt for the vibe or up by the quiet hotels near the Frankfurt Messe area. I highly recommend taking the trams anywhere. Buy an all-day ticket at any tram kiosk, again for about £5. Hop on/hop off. Great detailed maps at most of the tram stop. This was my favourite way to explore the city. If the scenery died out and got boring, I just hopped off, crossed the rails and took the next tram back in to central.
Like most in the trip: The first day best was walking from the Romer tram stop to Paulsplatz and finishing at Hauptwauche. Lots of shops, food and scenery. The second day was taking a train to Wiesbaden for a morning stroll amongst the beautiful buildings, then taking a 15-minute train from there to the small hamlet Walluf on the Rhine River for a 1-hour stroll and buying wine directly from the merchants."